Mutations and Base Sequence Errors
Mutations and Base Sequence Errors. Biology 30—Lab III.5 Page 4
PART C: Mutations and Base Sequence Errors
Not often are there errors in the process of forming proteins from the DNA code of instructions. An error in the process is a mutation and will result in formation of a different type of protein.
Save your time - order a paper!
Get your paper written from scratch within the tight deadline. Our service is a reliable solution to all your troubles. Place an order on any task and we will take care of it. You won’t have to worry about the quality and deadlines
Order Paper NowHemoglobin is a protein in red blood cells. Hemoglobin results from the proper arrangement of almost 600 amino acids. Most humans have the correct type of hemoglobin. However, in some people the arrangement is incorrect. These people have a disease called sickle-cell anemia. Their red blood cells are sickle shaped rather than round. As a result, the red blood cells cannot transport oxygen as well.
The following amino acid sequence represents a portion of the normal hemoglobin molecule:
proline, glutamate, glutamate, lysine.
1. Use the Data.pdf table to translate the sequence of amino acids in normal hemoglobin into the following codes. Remember that the table shows mRNA codes (use first listing of the amino acid in the table)
a) mRNA base codes
b) tRNA base codes
c) DNA base codes
In sickle-cell anemia, the sequence of amino acids is slightly different. It is
proline, valine, glutamate, lysine.
2. Translate the sequence of amino acids in sickle-cell hemoglobin into (use third valine in tables)
a) mRNA base codes
b) tRNA base codes
c) DNA base codes
3. In terms of base nucleotides, explain the only difference between the DNA message for normal hemoglobin and the DNA message for sickle-cell hemoglobin.
A mutation, therefore, is a difference from what we consider to be the normal sequence of bases in a molecule of DNA. The differences or error does not have to be very great. As you have just determined, a base sequence of only one triplet (three bases) can cause the formation of the wrong type of hemoglobin. A change at only one base site of the triplet can cause mutation.
4. How are mutations passed on to offspring?
DNA and RNA
Mutations and Base Sequence Errors
“Looking for a Similar Assignment? Get Expert Help at an Amazing Discount!”
